Iboga Detox is so effective as a tool because it blocks the physical withdrawals, while also helping the person to heal the wounds that led to their addictive behavior in the first place. With our Bwiti and science based program, the mental and spiritual healing guests receive is much greater than most sterilized Ibogaine Clinics can offer.&nbsp; Working with just Ibogaine is like using just one ingredient of a perfect dish. Ibogaine is just one of the active alkaloids found in Iboga. Iboga’s alkaloids have been found to have individual benefits, but also work together synergistically for optimal healing.&nbsp; Why would you change what is already perfectly made by nature itself?&nbsp; Not to mention, Iboga is actually much safer than Ibogaine as it actually is more effective due to the synergistic/individual benefits of these alkaloids and doesn’t require such high levels to be effective.&nbsp; Please read our article “Why Iboga is better than Ibogaine” to learn more.

Iboga V. Ibogaine

Depression and Mental Health Conditions Some of the antidepressant properties of Ibogaine may be due to its effects on activating receptors in the brain, such as the sigma-2 receptors (11).&nbsp; Once again, research reveals that Ibogaine is not the only alkaloid in Iboga activating these receptors.&nbsp; Tabernanthine is also a potent activator for the sigma-2, and the combination of alkaloids in the form of Iboga therapy may provide additional benefits against mental conditions such as depression (12).&nbsp;An Already Perfect Recipe Iboga and its alkaloids are already a natural perfect recipe for healing. Keep in mind that taking Iboga still brings the potency and effects of Ibogaine along with everything else. The science also clearly shows that the inclusion of the other alkaloids makes it the&nbsp;more effective option in attenuating the symptoms of drug craving/withdrawal&nbsp;and&nbsp;treating mental health conditions. The available Iboga treatments can vary, but practitioners usually use Iboga Root Bark, Iboga Total Alkaloid extract (TA), or a combination of the two. This is what we do at&nbsp;Root Healing Iboga Retreats&nbsp;and&nbsp;Iboga Detoxes.&nbsp;Comparing the Safety of Iboga and Ibogaine TherapyBoth Iboga and Ibogaine should be taken with&nbsp;proper supervision and care. However, Iboga is much safer and can be done safely after the proper medical screening.&nbsp;Ibogaine &amp; Noribogaine Ibogaine and its primary metabolite, Noribogaine, have inhibitory effects on ion channels in the heart, which regulate the electrical system of the cardiac muscle and the cardiac rhythm (13). The duration of these effects depends on the half-life of Noribogaine, which is 28-49 hours (14). Since the neutralization of Noribogaine occurs mainly in the liver, medications or diseases that block the liver metabolism can slow down the process and prolong the effect of the alkaloid on the heart.&nbsp; There are also some contraindicated medications that should be&nbsp;reviewed by an experienced team. This is because they either block the liver enzymes, ion channels in the heart, or both, which makes these drug-drug interactions potentially dangerous. Therefore, both Iboga and Ibogaine should be used only with a medical team or trained Iboga Providers, after undergoing a complete medical examination by an experienced physician.Iboga Root Bark and Iboga TA are much safer Nevertheless, using Iboga Root Bark or TA extract is widely considered much safer than Ibogaine alone since Noribogaine is the most dangerous metabolite. That’s because keeping the alkaloids such as tabernanthine (13-methoxy ibogamine), ibogamine, and coronaridine enhances the effects of Iboga and reduces the need for higher Ibogaine doses. At the same time, using a TA extract allows for dosing that is as precise as using Ibogaine alone while still receiving the benefits from all alkaloids and the interactions between them. Lower doses of Ibogaine in the system also carry lower risks of side effects. However, in our experience, weight-based dosing of Ibogaine which is common in most treatment centers is also not the most optimal approach. We have observed that tolerance and safety towards Iboga and Ibogaine are not related to body weight alone.&nbsp; Instead, we recommend dosing in progressive increments based on each individual’s physiological and psychological responses. The Spirit of Iboga - Godfather of Plant MedicinesThe most important aspect of a person’s healing is that Iboga’s spirit remains in the medicine.&nbsp;This will increase both efficacy and safety.&nbsp; The spirit of Iboga cannot be maintained in the creation of&nbsp;Ibogaine, which is the main reason it is less safe and lacks complete spiritual healing. In addition, in most available forms of TA, and even some Root Bark, the spirit is lost during extraction or handling.&nbsp; Growing, harvesting, and preparing the Root Bark requires traditional ceremonial practices properly, and TA must be made in a particular way to ensure the spirit remains. This is why the right Iboga and properly prepared Iboga TA are much more effective healing tools than Ibogaine.&nbsp;Summary Iboga Root Bark and properly prepared Iboga TA are much safer and more effective than Ibogaine. Iboga Root Bark and Iboga TA contain all of the beneficial alkaloids, which have both individual and synergistic benefits, enhancing the efficacy of each. Ibogaine is&nbsp;just&nbsp;a single extracted alkaloid. It has even been shown that a few alkaloids, such as Ibogamine, have stronger anti-addiction properties. Due to the presence of other alkaloids and the lower levels of noribogaine in the body, Iboga Root Bark and Iboga TA are also much safer.&nbsp; However, the presence of Iboga’s spirit is really what makes it superior to Ibogaine. Ibogaine is devoid of this and its spiritual and safety benefits.References: Zanda, M. T., &amp; Fattore, L. (2017). Novel Psychoactive Substances: A New Behavioral and Mental Health Threat. Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles, 341–353. https://doi.org/10.1016/B978-0-12-805373-7.00029-3&nbsp;Goutarel, R., Gollnhofer, O., &amp; Sillans, R. (1993). Pharmacodynamics and therapeutic applications of iboga and ibogaine. Psychedelic Monographs and Essays, 6, 70-111.Lotsof, H. S., &amp; Alexander, N. E. (2001). Case studies of ibogaine treatment: implications for patient management strategies.&nbsp;The Alkaloids. Chemistry and biology,&nbsp;56, 293–313. https://doi.org/10.1016/s0099-9598(01)56020-4Mash, D. C., Kovera, C. A., Pablo, J., Tyndale, R., Ervin, F. R., Kamlet, J. D., &amp; Hearn, W. L. (2001). Ibogaine in the treatment of heroin withdrawal.&nbsp;The Alkaloids. Chemistry and biology,&nbsp;56, 155–171. https://doi.org/10.1016/s0099-9598(01)56012-5&nbsp;Schenberg, E. E., de Castro Comis, M. A., Chaves, B. R., &amp; da Silveira, D. X. (2014). Treating drug dependence with the aid of ibogaine: a retrospective study.&nbsp;Journal of psychopharmacology (Oxford, England),&nbsp;28(11), 993–1000. https://doi.org/10.1177/0269881114552713&nbsp;Davis, A. K., Barsuglia, J. P., Windham-Herman, A. M., Lynch, M., &amp; Polanco, M. (2017). Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning.&nbsp;Journal of psychedelic studies,&nbsp;1(2), 65–73. https://doi.org/10.1556/2054.01.2017.009Wells, G. B., Lopez, M. C., &amp; Tanaka, J. C. (1999). The effects of ibogaine on dopamine and serotonin transport in rat brain synaptosomes.&nbsp;Brain research bulletin,&nbsp;48(6), 641–647. https://doi.org/10.1016/s0361-9230(99)00053-2&nbsp;Szumlinski, K. K., Maisonneuve, I. M., &amp; Glick, S. D. (2000). Differential effects of ibogaine on behavioural and dopamine sensitization to cocaine.&nbsp;European journal of pharmacology,&nbsp;398(2), 259–262. https://doi.org/10.1016/s0014-2999(00)00325-3&nbsp;Maisonneuve, I. M., Rossman, K. L., Keller, R. W., Jr, &amp; Glick, S. D. (1992). Acute and prolonged effects of ibogaine on brain dopamine metabolism and morphine-induced locomotor activity in rats.&nbsp;Brain research,&nbsp;575(1), 69–73. https://doi.org/10.1016/0006-8993(92)90424-8&nbsp;Glick, S. D., Kuehne, M. E., Raucci, J., Wilson, T. E., Larson, D., Keller, R. W., Jr, &amp; Carlson, J. N. (1994). Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.&nbsp;Brain research,&nbsp;657(1-2), 14–22. https://doi.org/10.1016/0006-8993(94)90948-2&nbsp;Skuza G. (2003). Potential antidepressant activity of sigma ligands.&nbsp;Polish journal of pharmacology,&nbsp;55(6), 923–934.&nbsp;Popik, P., &amp; Skolnick, P. (1999). Pharmacology of Ibogaine and Ibogaine-Related Alkaloids.&nbsp;Alkaloids: Chemistry and Biology,&nbsp;52(C), 197–231. https://doi.org/10.1016/S0099-9598(08)60027-9 `1Koenig, X., Kovar, M., Boehm, S., Sandtner, W., &amp; Hilber, K. (2014). Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.&nbsp;Addiction biology,&nbsp;19(2), 237–239. https://doi.org/10.1111/j.1369-1600.2012.00447.x&nbsp;Glue, P., Lockhart, M., Lam, F., Hung, N., Hung, C. T., &amp; Friedhoff, L. (2015). Ascending-dose study of noribogaine in healthy volunteers: pharmacokinetics, pharmacodynamics, safety, and tolerability.&nbsp;Journal of clinical pharmacology,&nbsp;55(2), 189–194. https://doi.org/10.1002/jcph.404What Is Ibogaine? Ibogaine&nbsp;was first discovered by Édouard Landrin in 1900. It’s also the alkaloid with the highest concentration in the plant and carries its psychoactive and medicinal properties (1). It was first used in western medicine during the 1930s as a stimulant and antidepressant (2). Three decades later, it was found that the alkaloid can suppress withdrawal symptoms and drug-seeking behavior in people addicted to heroin, morphine, cocaine, amphetamine, and alcohol (3). Numerous trials have showcased its effectiveness in attenuating symptoms of depression, drug addiction, and withdrawal (4, 5, 6). This includes withdrawal from opioids, cocaine, alcohol, and others. Since then, scientists have studied Ibogaine in isolation rather than as a part of the whole plant.Limitations of Research The plant’s legal status also limits research. Due to its psychedelic properties, Ibogaine is regarded as a Schedule I substance in the United States, which makes possession illegal under federal law. It is also regulated in many other countries worldwide.&nbsp; Meanwhile, Iboga and Ibogaine are used successfully as a treatment in several countries, including&nbsp;Portugal, Canada, New Zealand, Mexico, and&nbsp;Thailand.&nbsp;Summary of above: The Bwiti have used Iboga for thousands of years, and Ibogaine was discovered in 1900. However, most scientists have focused only on Ibogaine since its discovery, ignoring Iboga itself and the rest of the alkaloids. The legal status of Ibogaine as a scheduled drug has also limited scientific research.&nbsp; Why is Iboga Better Than Ibogaine? Even though Ibogaine has been studied chiefly in isolation rather than as a part of the Iboga, we believe that the natural combination the different alkaloids may further enhance the&nbsp;beneficial potential&nbsp;for treating addiction and depression. Furthermore, research on other alkaloids has found that they are almost equally effective.&nbsp;Addiction According to the research, Ibogaine works by modulating several receptors and neurotransmitters in the brain, such as dopamine. By blocking dopamine uptake, the alkaloid can reset its levels and attenuate addiction and withdrawal symptoms (7). Scientists reveal that the process can reverse the dopamine sensitization induced by drugs, which is the underlying cause of these symptoms (8). What is more, Ibogaine provides a prolonged reduction in the stimulatory effect of&nbsp;opioids&nbsp;and cocaine on dopamine levels (9). Yet, Ibogaine is not the only active alkaloid in the root bark of the&nbsp;Tabernanthe Iboga&nbsp;shrub. Iboga contains dozens of alkaloids, and preliminary research suggests that most can enhance its medicinal benefits. For example, researchers have found that other alkaloids such as tabernanthine (13-methoxy ibogamine), ibogamine, and coronaridine also modify the dopamine levels in the brain and enhance potent effects against addiction and withdrawal on their own (10). In fact, one of the alkaloids called Ibogamine was even more potent than Ibogaine in inducing abstinence in rats addicted to cocaine and morphine. This means that the benefits of Ibogaine will be potentiated when used in conjunction with the rest of the alkaloids.Iboga, also known as the godfather of all plant medicines, contains many alkaloids capable of providing powerful healing effects.&nbsp; Researchers have discovered dozens of compounds in the Tabernanthe Iboga shrub, but most remain untested as therapeutic agents. Thus, the true power of Iboga may come from several molecules or even the interaction between them. Meanwhile, the standard medical approach uses only one&nbsp;alkaloid – Ibogaine&nbsp;– which is proven to alleviate symptoms of drug addiction, withdrawal, depression, PTSD, and other mental health conditions. Studies have also shown that it may even help with&nbsp;Parkinson’s,&nbsp;Autoimmune diseases, Viruses (HIV, Hepatitis), and other physical conditions.&nbsp; While Ibogaine has all this fantastic research behind it, it is just one of the active alkaloids in Iboga. What’s more, Iboga is a plant medicine with an intelligent healing spirit, and by the time you have extracted Ibogaine, the spirit will be gone. So, taking Iboga instead of Ibogaine is much more beneficial for healing for several reasons, which we will discuss below.&nbsp;What Is Iboga? Iboga is the inner root bark of an African shrub called&nbsp;Tabernanthe Iboga. The inner root bark is utilized because it contains the highest alkaloid content. Tabernanthe Iboga is indigenous to equatorial West Africa, and the Babongo of Southern Gabon were the first to discover its medicinal benefits. Iboga continues to be the sacrament of the Bwiti spiritual tradition.&nbsp; Traditionally, the root bark is ground into a powder and taken in this form,&nbsp; However, it is sometimes consumed as a tea. The&nbsp;Bwiti&nbsp;practitioners use Iboga for&nbsp;initiation rituals, ceremonies, mental/physical/spiritual stimulation, healing, spiritual growth, and guidance. This shrub contains at least 12 alkaloids with concentrations up to 6% in the inner root bark, which contributes to its hallucinogenic, spiritual, and healing properties. Yet, the essential aspect of its ability to heal is the intelligent spirit it contains.

Root Healing Maine • Retreat Center

Iboga V. Ibogaine

Ibogaine vs. Iboga - Which One is Better?