Scientists at University College London have published the first detailed neuroscientific investigation of 5 MeO D MT, often described as one of the most powerful natural compounds ever studied. Unlike L SD or psilo cyb1n, which typically increase brain activity and connectivity, high dose 5 MeO D MT produced the opposite effect. In this study of 29 healthy volunteers, EEG recordings showed the brain shifting into slow wave patterns normally associated with deep sleep or general anesthesia. Yet participants were fully awake and reporting some of the most intense conscious experiences of their lives. Researchers described this state as “deconstructed consciousness.” The brain appeared unable to form the usual distinctions and mental categories that structure our everyday reality, while still maintaining awareness. The study was published in Cell Reports in August 2025 by researchers at University College London, including first author George Blackburne. Scientists believe the EEG markers identified in this psyched3lic study may help track peak or mystical type experiences that are often linked to therapeutic outcomes. 5 MeO D MT is currently being studied in clinical research for depression, bipolar disorder, and alcohol use disorder. Findings like these could help researchers better understand how powerful psyched3lic experiences interact with brain networks involved in mood and perception. Sources Cell Reports, Blackburne et al., August 2025 UCL Faculty of Brain Sciences press release, January 19, 2026 Technology Networks, January 20, 2026 #BrainScience #Neuroscience #Consciousness #ScienceTok #BrainResearch